Welcome to GRK 1910

GRK 1910 is a joint Research Training Group funded by the Deutsche For-schungsgemeinschaft (DFG) focussing on the medicinal chemistry of selective GPCR ligands.

The Research Training Group is located at the Friedrich-Alexander University Erlangen-Nürnberg and the University Regensburg.

The program started on 1st October 2013.


More information about GRK 1910.

 

 

 

 

 

 

 

 


NEWS


Summer School on Medicinal Chemistry 2016

14.11.2016

The 8th International Summer School “Medicinal Chemistry”, organized by the DFG Research Training Group GRK1910 “Medicinal Chemistry of Selective GPCR Ligands”, took place at the University of Regensburg, September 21 – 23, 2016. Sixteen distinguished scientists from academia and industry accepted the invitation to contribute to a program combining teaching and cutting-edge research.

read full report

Talk Prof. Nigel Bunnett

10.11.2016

Prof. Dr. Nigel Bunnett (Colombia University, NY) will give a talk entitled "G Protein-coupled receptors: Dynamic machines for signaling pain, itch and neurogenic inflammation".

Date: 21.11.2016, 5.15 p.m.

Venue: FAU, lecture hall Schuhstraße 19

more information


Retreat 2016

14.07.2016

This year the retreat will be devided into two parts.

The PhD students and postdocs will meet on July 21st-22nd at Berghotel Sammüller in Neumarkt. At the same time, the PIs and coordinators meet at the Strandhotel Seehof in Langlaus

Retreat program


8th Summer School "Medicinal Chemistry"

16.06.2016

The 8th Summer School "Medicinal Chemistry" organized and presented of the GRK1910 will take place in Regensburg on 21st-23rd September 2016.

For more informtion, see: Summer School 2016

Program of Summer School


Research Day 2016

10.06.2016

The Research Day of the Emil Fischer Graduate Programme will take place on July 7th 2016.

Venue: Institute of Biochemistry, Fahrstrasse 17, Erlangen

Invitation and program


Talk Prof. Kevin Burgess

27.04.2016

Prof. Dr. Kevin Burgess (Texas A & M University) will give a talk entitled "Using EKO to sample conformational sweet-spots in peptidomimetic design".

Date: 02.06.2016, 5.15 p.m.

Venue: FAU, lecture hall Schuhstraße 19

more information


GRK1910 workshop with Kevin Burgess

27.04.2016

On June 7/8, 2016, Kevin Burgess from the Texas A&M University will give a workshop for GRK1910 members.

The workshop will start on June 7th at 2 pm and will end on June 8th at 1 pm on the campus of the University of Regensburg, Biology building, room DE 2.121.

Prelimimary program

Workshop syllabus


Talk Dr. Irene Coin

27.04.2016

Dr. Irene Coin (University Leipzig) will give a talk entitled "Genetically incorporated chemical probes for GPCR studies".

Date: 01.06.2016, 5.15 p.m.

Venue: FAU, lecture hall Schuhstraße 19

more information


Talk Prof. Dr. Bernhard Wünsch

20.04.2016

Prof. Dr. Bernhard Wünsch (Universität Münster) will give a talk at the FAU entitled "GluN2B selective NMDA receptor antagonists".

Date: 22.06.2016, 5.15 p.m.

Venue: FAU, lecture hall Schuhstraße 19

more information


3rd Conference on Impedance-Based Cellular Assays (IBCA2016) in Regensburg

The 3rd conference on impedance-based cellular assays will be hosted by the Universitaet Regensburg from August 9th till 12th.

More details on program and registration can be found on the conference website (http://www.ibca2016.net).


High-Class GPCR Meeting organized by GLISTEN and GRK1910

12.04.2016

As an initiative of the COST-funded GLISTEN network in collaboration with the GRK 1910 research group an outstanding group of GPCR experts from the research community and industry met in Erlangen to discuss the latest and hottest topics regarding ligand-receptor interactions, crystal structures and transmembrane signalling.

Over 170 participants had to chance to attend the talks of highly prominent speakers including Nobel laureate Brian Kobilka. Additionally, 75 posters were presented during two sessions. 

see also:   

Conference program

Feedback of participants


Talk Prof. Dr. Takeaki Ozawa

03.03.2016

Prof. Dr. Takeaki Ozawa (University of Tokyo) will give a talk entitled "Luminescent sensors and optical switches for single cell analysis".

Date: 10.03.2016, 5.15 p.m.

Venue: UR, lecture hall DE 2.133

more information


8th Summer School "Medicinal Chemistry"

08.02.2016

The 8th Summer School "Medicinal Chemistry" organized and presented of the GRK1910 will take place in Regensburg on 21-23th September 2016.

For more informtion, see: Summer School 2016


GRK Seminar "Good Scientific Practice"

13.01.2016

Seminar on "Good Scientific Practice" featuring

Dr. Brian Johnson (Wiley), who gives a talk entitled "Cases and Consequences of Scientific Misconduct – A Publisher’s View",

and

Prof. Christoph Meinel (Department of Philosophy and Humanities, UR)

Date: 10.02.2016, 3.00 p.m.

Venue: UR, lecture hass H46


Workshop at Amgen Research GmbH in Regensburg

10.11.2015

A group of RTG fellows visited the high throughput screening facilities of Amgen Research GmbH in Regensburg.

According to official numbers the HTS lab screeens more than 15 million compounds per year for a variety of different targets. After an introductory talk describing Amgen's screening approaches and strategies, a tour through the HTS labs provided a vivid impression about lab automation and standardization. The day was completed by a mini-workshop on label-free approaches to monitor cell-based assays with special emphasis on GPCR as targets.


Talk Prof. Dr. Takeaki Ozawa

26.10.2015

Prof. Dr. Takeaki Ozawa (University of Tokyo) will give a talk entitled "Luminescent sensors and optical switches for single cell analysis".

Date: 25.11.2015, 5.15 p.m.

Venue: FAU Erlangen-Nürnberg

more information


Talk Prof. Dr. Clemencia Pinilla

22.10.2015

Prof. Dr. Clemencia Pinilla (Torrey Pines Institute for Molecular Studies, San Diego) will give a talk entitled "Positional Scanning Libraries: Concepts, Identification of GPCR ligands and Elucidation of T cell specificity".

Date: 11.11.2015, 5.15 p.m.

Venue: FAU Erlangen-Nürnberg

more information


Workshop on High Troughput Screening

14.10.2015

On Monday, November 9, GRK members will visit the High Throuput Screening facilities of Amgen (https://www.amgen.de/) in Regensburg in the morning, followed by a mini-workshop on label-free technologies in the afternoon.

On Tuesday, November 10, Dr. Clemencia Pinilla from the Torrey Pines Institute for Molecular Studies (http://www.tpims.org/our-scientists/california-team/clemencia-pinilla) will give a workshop on the use of synthetic combinatorial compound libraries for the de-novo identification of bioactive compounds, in Erlangen.


Retreat 2015: Hot scientific discussions on Schloss Thurnau

24.07.2015

At very summery temperatures above 30°C the second retreat of the Research Training Group took place on 22st-23nd July.  After two great talks by Prof. Uwe Sonnewald and Prof. Torsten Kuwert the RTG members reported on their current projects, which formed the starting point for many fruitful and lively discussions. 

To see some impressions of the retreat, please click on the picture below.


Research Day 2015

22.06.2015

The Research Day of the Emil Fischer Graduate Programme will take place on July 9th 2015.

Venue: Institute of Biochemistry, Fahrstrasse 17, Erlangen

Invitation and program


Talk Prof. Dr. Mette Rosenkilde

19.05.2015

Prof. Dr. Mette Rosenkilde (University of Copenhagen) will give a talk entitled "Constitutive and biased signalling of chemokine receptors".

Date: 01.07.2015, 5.15 p.m.

Venue: FAU Erlangen-Nürnberg

more information


Talk Prof. Dr. Léon Ghosez

29.04.2015

Prof. Dr. Léon Ghosez (Institut Européen de Chimie et Biologie Bordeaux/Pessac – France) will give a talk entitled "Design and synthesis of natural-inspired scaffolds as an invaluable source of molecules of therapeutic interest".

Date: 06.05.2015, 5.15 p.m.

Venue: FAU Erlangen-Nürnberg

more information


Date and venue confirmed for Retreat 2015

02.04.2015

We are happy to announce that the date and venue of the Retreat 2015 can now be confirmed.

The event will take place on July 22nd-23rd at Schloss Thurnau west of Bayreuth. 

More information will be provided shortly.


Talk Dr. Tobias Langenhan

02.04.2015

Dr. Tobias Langenhan (University Würzburg) will give a talk entitled "Adhesion-GPCRs - a novel class of metabotropic mechanoreceptors?".

Date: 07.05.2015, 5.15 p.m.

Venue: Uni Regensburg

more information


Talk Prof. Dr. Jens Carlsson

11.03.2015

Prof. Dr. Jens Carlsson (Stockholm University) will give a talk entitled "Successes and failures in structure-based discovery of GPCR ligands: Two steps forward, one step back".

Date: 22.04.2015, 5.15 p.m.

Venue: Lecture Hall, Schuhstrasse 19, FAU Erlangen-Nürnberg

more information


Talk Prof. Dr. Masha Niv

26.01.2015

Prof. Dr. Masha Niv (The Hebrew University of Jerusalem) will give a talk entitled "Bitter compounds and their receptors: selectivity, promiscuity and open questions".

Date: 26.02.2015, 5.15 p.m.

Venue: Lecture Hall, Schuhstrasse 19, FAU Erlangen-Nürnberg

more information


Talk Dr. Peter Kolb

26.01.2015

Dr. Peter Kolb (Philipps-Universität Marburg) will give a talk titled "Interactions between GPCRs and ligands: Screening, selectivity and mechanism".

Date: 02.02.2015, 5.15 p.m.

Venue: Multimedia-Seminarraum of CCC, Nägelsbachstr. 25, FAU Erlangen-Nürnberg

more information


Talk Prof. Dr. Felix Engel

26.01.2015

Prof. Dr. Felix Engel (Universitätsklinikum Erlangen) will give a talk titled "Adhesion GPCRs".

Date: 28.01.2015, 5.15 p.m.

Venue: Lecture Hall, Schuhstrasse 19, FAU Erlangen-Nürnberg

more information


Post-doc position available

16.12.2014

The Research Training Group “Medicinal Chemistry of Selective GPCR Ligands” (GRK 1910) offers

1 Post-Doc Position (TV‐L E13, 100%)

Associated to the Laboratory of Prof. Peter Gmeiner (Chair of Pharmaceutical/Medicinal Chemistry), Friedrich-Alexander University Erlangen-Nürnberg

read full job advertisement


Talk Prof. Dr. Oliver Zerbe

05.11.2014

Prof. Dr. Oliver Zerbe (University Zürich) will give a talk titled "Towards structures of G-protein coupled receptors by solution NMR".

Date: 10.12.2014, 5.15 p.m.

Venue: FAU, Lecture Hall, Schuhstraße 19, 91052 Erlangen

more information


Talk Prof. Dr. Heinz H. Pertz

04.11.2014

Prof. Dr. Heinz H. Pertz (FU Berlin) will give a talk titled "Serotonin - Native Receptor Subtypes and their Role in the Cardiovascular System".

Date: 26.11.2014, 5.15 p.m.

Venue: FAU, Lecture Hall, Schuhstraße 19, 91052 Erlangen


Summer School 2014

25.10.2014

The 7th Summer School “Medicinal Chemistry” took place from 17th-19th Sep in Regensburg. Speakers from all around the world were invited to present their latest findings in drug research, GPCR structure and function as well as anti-infectives. PhD students presented their projects by posters or short oral presentations. The dinner in the evening provided an excellent framework for fruitful scientific and non scientific discussions.

To see some impressions of the event, please click on the picture below.


Talk Dr. Mélanie Hall

20.10.2014

Dr. Mélanie Hall (Department of Chemistry, University of Graz, Austria) will give a talk on the "Development of Biocatalytic Tools for the Synthesis of Enantiopure Molecules".

Date: 29.10.2014, 5.15 p.m.

Venue: Lecture Hall H46, Organic Chemistry, University Regensburg

 

more information


Post-doc position available

24.09.2014

The Research Training Group “Medicinal Chemistry of Selective GPCR Ligands” offers 1 Post-Doc Position (TV‐L E13, 100%) at the University of Regensburg (Germany).

Project Title: Mapping GPCR-Activation in Adherent Cell Monolayers using imaging SPR (SPRi)

 

more information


Retreat 2014: "What belongs together, grows together"

24.07.2014

The first retreat of the Research Training Group took place on 21st-22nd July.  After two days with great talks by Prof. Roland Seifert and Prof. Joachim Hornegger, 24 progress reports of the PhD students and postdocs, and a lot lot of fruitful communication the group really welded together.

To see some impressions of the retreat, please click on the picture below.


Research Day 2014

03.07.2014

The Research Day of the Emil Fischer Graduate Programme will take place on July 10th 2014.

Venue: Institute of Biochemistry, Fahrstrasse 17, Erlangen

Invitation and program


Partnership with New International Graduate Program

21.05.2014

The GRK 1910 is proud to announce the partnership with the new international graduate program "Receptor Dynamics: Emerging Paradigms for Novel Drugs". This program is a joint initiative of the Universities of Würzburg, Bayreuth, Erlangen-Nürnberg, and Regensburg and is funded by the Elite Network of Bavaria, Germany.

The FAU Erlangen-Nürnberg and the University Regensburg offer one PhD Position each:

FAU: Irreversibly-binding GPCR ligands and slowly diffusing analogs

UR: Temporal dynamics of GPCRs: ligand-dependent stabilization of receptor conformations, residence time and insurmountable antagonism

 

For more information about the graduate program and the application process, see >Receptor Dynamics: open positions

Deadline for applications: 15 June 2014


7th Summer School "Medicinal Chemistry"

13.05.2014

The 7th Summer School "Medicinal Chemistry" organized and presented of the GRK1910 will take place in Regensburg on 17-19th September 2014.

For more informtion, see: Summer School 2014

Program of Summer School


Date and venue confirmed for Retreat 2014

05.03.2014

We are happy to announce that the date and venue of the Retreat 2014 can now be confirmed.

The event will take place on July 21st-22nd at the conference hotel Behringers next to Gößweinstein in the "Fränkische Schweiz". 


1. Workshop 2014

17.02.2014

   Current members of the GRK 1910 (click to enlarge) 

The first workshop of our Research Training Group was held in Regensburg on February 13-14th. 

Doctoral students, postdocs and supervisors met to get to know each other and to learn about all the starting research projects and teaching events. Additionally, Prof. Dr. Morten Grøtli (University of Gothenburg) gave a lecture about developing MEK and RET Inhibitors. Prof. Tim Clark introdoced the brand new web-based modeling server.

The assembly of graduates and postdocs elected Kilian Kuhn (UR) and Thorsten Schäfer (FAU) as Student representatives.

 

Some impressions of the workshop: (click to enter picture gallery)


Kick-off Meeting

22.11.2013

The first official event of the Research Training Group took place on November 21st. The FAU hosted the Kick-off Meeting featuring the following four invited speakers:

Prof. Dr. Rob Leurs (VU University Amsterdam)

Prof. Dr. Annette Beck-Sickinger (University Leipzig)

Prof. Dr. Christa Müller (University Bonn)

Prof. Dr. Elliott Richelson (Mayo Clinic, Jacksonville, Florida)

 

Official program (pdf)

 

Pictures taken at the Kick-off Meeting: (click to enter image gallery)