Wednesday, April 6^th

9:00-12:00

GPCRdb Satellite Meeting

12:45

Opening

13:00

Brian Kobilka (Stanford University)

Structural insights into the dynamic process of GPCR signaling

Session 1

Chairs:

Peter Gmeiner, Maria Marti

13:50

Gebhard F. X. Schertler (Paul Scherrer Institut, Villigen)

The application of Free Electron Lasers to biology: a new age of time resolved crystallography

14:25

Reinhard Grisshammer (NIH, Maryland)

Structure and dynamics of the neurotensin receptor

15:00

Coffee break

15:45

Chris Tate and Byron Carpenter (MRC, Cambridge)

Structure of the human adenosine A2a receptor bound to an engineered G protein

Session 2

Chairs:

Zita Liutkeviciute, Sabina Podlewska

16:20

Sébastien Granier (IGF Montpellier)

Structural studies of opioid receptor activation

16:55

Xavier Deupi (Paul Scherrer Institut, Villigen)

Backbone NMR spectroscopy reveals allosteric activation networks in the β1 adrenergic receptor

17:30

Christoph Klenk (University of Zürich)

A generic system for improved expression and thermostability of G protein-coupled receptors by directed evolution

17:45

Peter Hildebrand (Charité Berlin)

Position of transmembrane helix 6 determines receptor G protein coupling specificity

18:15

Poster and welcome reception

Thursday, April 7^th

8:45

GPCRdb Demo

9:30

Brian Shoichet (UCSF)

Structure-based discovery of new ligands leading to new GPCR biology

Session 3

Chair:

Zoran Sucur

10:05

Peter Kolb (Universität Marburg)

GPCR ligand selectivity and chemistry

10:40

Jens Carlsson (Uppsala University)

Structure-based screening for GPCR ligands from fragment and lead-like chemical space

11:15

Coffee break

11:45

Christa Müller (Universität Bonn)

Adenosine A_2A and A_2B receptors: close relatives with crucial differences

Session 4

Chair:

Christian Munk

12:20

Holger Stark (Universität Düsseldorf)

Histamine H3 Receptor Antagonists – Selectivity vs. Promiscuity

12:55

Olivier Corminboeuf (Actelion)

FPR2/ALXR agonists: Lead optimization and application in a mouse model of Alzheimer’s disease

13:10

Lunch / Poster session

14:10

GLISTENdb Workshop

14:40

Martin Caffrey (Trinity College, Dublin)

Membrane Protein Structure - Function Studies With Lipid Mesophases

Session 5

Chairs:

Stefan Mordalski, Johanna Tiemann

15:15

Moritz Bünemann (Universität Marburg)

GPCRs under control of voltage: Mechanisms and effects of voltage on GPCR activation

15:50

Jana Selent (UPF Barcelona)

A gate for membrane cholesterol into the interior of GPCRs

16:05

Dorothée Möller (FAU Erlangen)

D₂R/NTS₁R Heterodimer-Selective Ligands

16:20

Cedric Govaerts (Universite Libre de Bruxelles)

Allosteric regulation of G protein-coupled receptor activity by phospholipids

16:35

Coffee break

17:15

Jean-Louis Reymond (Universität Bern)

Chemical Space for Drug Discovery

Session 6

Chairs:

Tim Knehans, Max Keller

17:50

Ulrike Holzgrabe (Universität Würzburg)

Orthoster, Alloster, Dualster – tools to switch the muscarinic receptor

18:25

Marcello Leopoldo (Università degli Studi di Bari)

Ureidopropanamide derivatives for studying the role of formyl peptide receptor 2 in neuroprotection

18:40

Tizita Admas (FAU Erlangen)

Development of photoactivatable probes for labeling of the human chemokine receptor CXCR3

18:55

Xavier Leroy (Actelion)

Humanin peptide: A potent agonist of GPR1, a beta-arrestin specifically coupled receptor

20:15

Conference dinner (Palmeria Erlangen)

Friday, April 8^th

8:00-9:30

Management Committee Meeting

9:30

Yves Auberson (Novartis)

Histamine H3 inverse agonists for the treatment of narcolepsy: Optimizing with a clinical profile in mind

Session 7

Chair:

Christoph Klenk

10:05

Susanne Roth (Novo Nordisk)

Exploring GPCR signalling with mathematical models

10:40

Mickey Kosloff (University of Haifa)

Computational interrogation of multi-specificity determinants in G proteins

10:55

Coffee break

11:25

Roger Sunahara (UCSD)

Allostery in the coupling of G proteins to G protein-coupled receptors

Session 8

Chair:

Anni Allikalt

12:00

Selma Anton (Universität Würzburg)

Identification and characterization of cAMP compartments in living cells

12:15

Martin Lohse (Universität Würzburg)

Watching receptor signaling in space and time

12:50

Closing remarks

13:00

End of GLISTEN Meeting