Following the integrated concept of the GRK1910 all research projects are highly collaborative and interdisciplinary. Doctoral projects are supervised by at least 3 group leaders. The name of the primary supervisor of each project is given below. The majority of projects are aimed to be handles by a graduate student within three-year doctoral studies. Additionally, some projects are designed to give talented postdoctoral researches the opportunity to further qualify and to take advantage of the interdisciplinary environment of the GRK1910 for up to 2 years.
Following an integrated concept, 13 collaborative doctoral Projects are addressed within the research Training Group. Additionally, postdoctoral projects are intended to promote the careers of highly talented and motivated junior scientists and to improve networking between the project groups by exploring new approaches and techniques of particular importance in the field.
The projects, which are assigned to the research areas A, B and C, aim to better understand selectivity principles of GPCR-ligand interactions and to exploit this knowledge for a rational design of highly selective GPCR ligands. The project proposals P are intended to promote the careers of highly talented and motivated junior scientists and to improve networking between the project groups by exploring new approaches and techniques of particular importance in the field.
A) Selective GPCR-ligand interactions
Projects to understand and control selectivity; Structure or ligand based design, ligand synthesis, binding studies and functional assays, mutagenesis discovery of ligands with novel selectivity profiles.
B) Selective GPCR tracers and tools
Synthetically driven projects establish crucial methodology and apply for tools (PET ligands, switchable ligands).
C) Selective GPCR-mediated signal transduction
Projects to develop and apply individual assays to characterize selective ligands integratively (proteomics, label-free assays, ion channel modulation).
|Project area A|
|A1||Development of functionally selective GPCR ligands||Prof. Peter Gmeiner|
|A2||Histamine receptor ligands: Subtype, functional and ortholog selectivity||PD Dr. Andrea Strasser|
|A3||Bifunctional histaminergics (terminated)||PD Dr. Andrea Strasser|
|A4||Dualsteric ligands for muscarinic acetylcholine receptors||Dr. Max Keller|
|A5||Allosteric GPCR modulation by small-molecule CXCR3 ligands (terminated)||Dr. Nuska Tschammer|
|A6||Understanding the principles of selectivity by homology modeling and simulation of ternary complexes||Prof. Tim Clark|
|A7||Peptide-like and non-peptidic selective ligands for the neuropeptide Y Y4receptor||Dr. Max Keller|
|A8||Effect of GPCR sequence variability on ligand binding properties||Prof. Heinrich Sticht|
|Project area B|
|B1||Photochromic GPCR ligands||Prof. Burkhard König|
|B2||Selective neuropeptide receptor radioligands for imaging studies in vivo by positron emission tomography (PET)||Prof. Olaf Prante|
|B3||Synthesis of selective GPCR ligands by "late stage" functionalization||Prof. Markus Heinrich|
|Synthetic GPCR mimics||Prof. Jutta Eichler|
|B5||Peptidergic GPCR ligands with unnatural amino acids||Prof. Oliver Reiser|
|Project area C|
|C1||Label-free analysis of GPCR activation in adherent cells||Prof. Joachim Wegener|
|C2||Targeted proteome analysis for the analysis of GPCR mediated signal transduction||Prof. Monika Pischetsrieder|
|C3||GPCR-mediated modulation of ion channels (will be terminated)||Prof. Kristina Friedland|
|C4||Bivalent ligands targeting homo- or heterodimers of dopamine D2-like receptors||Dr. Dorothée Weikert|
|C5||Deciphering signaling pathways for LPAR-dependent gene transcription and tumor therapy||Prof. Susanne Mühlich|
|Project area P|
|P1||Conformational control of GPCRs by functionally selective ligands||Prof. Peter Gmeiner|
|P2||Mapping GPCR-activation in adherent cell monolayers using imaging SPR||Prof. Joachim Wegener|